Quantum Buckyball Posted March 19, 2014 Share Posted March 19, 2014 What do you call (name) an enzyme that can perform three different catalytic reactions? Link to comment Share on other sites More sharing options...
rexzeppelin Posted March 20, 2014 Share Posted March 20, 2014 Can't tell if this is an earnest question or the set-up for a joke. In any event, I don't know the answer elanorci 1 Link to comment Share on other sites More sharing options...
Quantum Buckyball Posted March 20, 2014 Author Share Posted March 20, 2014 It was a serious question, we always learned name an enzyme after a specific catalytic reaction...but what if there are more than one reaction an enzyme can carry out? Do you just name it based on the catalytic reaction with the fastest kcat/km ? Link to comment Share on other sites More sharing options...
rexzeppelin Posted March 20, 2014 Share Posted March 20, 2014 That sounds like a reasonable convention. I mean, aren't some proteins named before all their functions have been elucidated, sometimes making the original names almost irrelevant? Link to comment Share on other sites More sharing options...
Quantum Buckyball Posted March 20, 2014 Author Share Posted March 20, 2014 yeah, usually it's called putative xxxxx based on the dna/aa sequences... and that's about it. Link to comment Share on other sites More sharing options...
ion_exchanger Posted March 20, 2014 Share Posted March 20, 2014 (edited) Do the functions occur at the same time? Is one reaction more favored than the others? I hope to name a novel protein/gene. I'll take into account the function(s) and name it in such a way that it has a cool acronym. Edited March 20, 2014 by ion_exchanger Link to comment Share on other sites More sharing options...
Quantum Buckyball Posted March 21, 2014 Author Share Posted March 21, 2014 No, not all 3 reactions occur simultaneously, Link to comment Share on other sites More sharing options...
username1824 Posted March 21, 2014 Share Posted March 21, 2014 Whichever function was found first was probably how it was named. I remember there's a protein called xxx kinase (the name escapes me), but the protein never comes in contact with xxx in vivo. It was just seen to add phosphate groups to xxx in vitro, so it was given the name and it stuck. Link to comment Share on other sites More sharing options...
elanorci Posted March 21, 2014 Share Posted March 21, 2014 I too was waiting for a pun. Darn. Link to comment Share on other sites More sharing options...
ion_exchanger Posted March 21, 2014 Share Posted March 21, 2014 Whatever it is should end in triase, no? Link to comment Share on other sites More sharing options...
rexzeppelin Posted March 21, 2014 Share Posted March 21, 2014 triumvirase?? suurkate, Vene and pcsteak 3 Link to comment Share on other sites More sharing options...
pcsteak Posted March 22, 2014 Share Posted March 22, 2014 triumvirase?? I believe we have a winner! Alternatively: trifectase. Link to comment Share on other sites More sharing options...
ion_exchanger Posted March 22, 2014 Share Posted March 22, 2014 Trifectase is pretty awesome! Link to comment Share on other sites More sharing options...
aberrant Posted March 22, 2014 Share Posted March 22, 2014 http://www.fastbleep.com/biology-notes/40/116/1159 I thought it is quite common that an enzyme can catalyze more than 1 reaction. Something like this (http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1W85&bionumber=1) can be considered as transketolase, dehydrogenase/oxidoreductase, & synthase. I would assumed naming of a protein is based on the main function it performs. Quantum Buckyball 1 Link to comment Share on other sites More sharing options...
Quantum Buckyball Posted March 23, 2014 Author Share Posted March 23, 2014 http://www.fastbleep.com/biology-notes/40/116/1159 I thought it is quite common that an enzyme can catalyze more than 1 reaction. Something like this (http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1W85&bionumber=1) can be considered as transketolase, dehydrogenase/oxidoreductase, & synthase. I would assumed naming of a protein is based on the main function it performs. Ohh that's a good website, thank you! Link to comment Share on other sites More sharing options...
Vene Posted March 24, 2014 Share Posted March 24, 2014 http://www.fastbleep.com/biology-notes/40/116/1159 I thought it is quite common that an enzyme can catalyze more than 1 reaction. Something like this (http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1W85&bionumber=1) can be considered as transketolase, dehydrogenase/oxidoreductase, & synthase. I would assumed naming of a protein is based on the main function it performs.I imagine it's got to be difficult to determine what an enzyme's main function happens to be. I guess you could try and assay the activity of different reactions it catalyzes in a cell in order to see what it spends the most time doing, but to truly say that a certain reaction is the primary reaction you have to justify it for all cell types and during different metabolic conditions. Link to comment Share on other sites More sharing options...
Quantum Buckyball Posted March 25, 2014 Author Share Posted March 25, 2014 or is it based on the turnover number....? Link to comment Share on other sites More sharing options...
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