I'm probably late on this, but maybe someone will find this useful in the future. There's a lot of great advice that's already been laid out in other replies, but I will offer two things that some folks were starting to hint at. They made all the difference for me in times of anxiety and stress in grad school: 1.) (Pro)actively define, or re-define, your well-being so that your happiness, satisfaction, and comfort in life is only partially dependent on grad school. Academia teaches us to focus inwardly, all the time. Find activities and resources that allow for interaction and or engagement with people who are not fully engrossed by their research, or engage in a service that requires no overly-analytical thinking (e.g. volunteer, or tend a community garden plot). Having this multi-dimensional criterion for your well-being and persona means that when your external hard drive with all your backed up data gets eaten by the neighbor's pitbull, you don't fall as hard. The world does not end, and you still have your tomatoes. 2.) Know that it is perfectly okay to not know. It can be terrifying to be out of your comfort zone, and in a community of hyper-critical/analytical peers, especially when there is an unfamiliar topic or complex research problem at hand. Showing your vulnerability, and having self-awareness of your strengths and weaknesses and being honest about them is one of the most refreshing, yet rare things that a grad student can do. You'd be amazed at how the atmosphere changes in a class discussion or lab meeting when someone simply confesses that they are at a loss, or just don't know. Likewise, if something isn't working with your advising situation, just lay it out on the table, because it happens all the time, and students go through undue stress trying to tolerate situations with fairly easy fixes. Regarding the new environment, the original poster is likely reveling in their new adventure at this point, because that's what it is. The last time that I got worked up over my research trajectory I received a small card in the mail from a former professional development adviser, with just one hand-written line: "You'll always have the potential for stress; try to enjoy the ride". Hope you're enjoying yours!