I don’t think you understand the term “optogenetics”.
GCaMP protein imaging techniques are the most successful in vivo calcium imaging tools and are optogenetic tools.
Chen, Tsai-Wen, et al. "Ultrasensitive fluorescent proteins for imaging neuronal activity." Nature 499.7458 (2013): 295-300.
Many tools within the optical pharmacology field are optogenetic tools.
Kramer, Richard H., Alexandre Mourot, and Hillel Adesnik. "Optogenetic pharmacology for control of native neuronal signaling proteins." Nature neuroscience 16.7 (2013): 816-823.
You can use SLM microscopy for optogenetic tools.
Packer, Adam M., et al. "Two-photon optogenetics of dendritic spines and neural circuits." Nature methods 9.12 (2012): 1202-1205.