notFBI

Wow, your profile is so similar to mine! Congratulations! Also, completely agree on working on a backup plan. International applicants' competition can get quite crazy!

Adding my experience here for international applicants who are shit scared like I was around three months back. International applicant from a reputed institute, at least in India. My SOP focused on Computational Structural Biology, although I am flexible. I lean towards computational modelling of bio systems in general.
Here's my list:
Bio@Purdue: Got an offer last week BSB@SUNY-SB: Interviewed. Waiting BMMB@Penn State: Waitlisted. UW: rejected QCB@BCM: rejected CBB@USC: rejected CBB@Duke: rejected Bio and Neuro @MSSM: rejected Plus I have been offered a position in a German lab. Found the ad on Euraxess. I love the project and the supervisor seems great, so I may take this one. If you are an international applicant waiting on US uni results, I suggest you work on backup plans by applying to other places like me.
Stats:
CGP: 8.0/10.0 (somehow doesn't seem to matter much unless you are applying to some top-tier uni) Bioinformatics and molecular modelling background; Interdisciplinary coursework - mostly in bio, chem, and math, in that order Languages: Python, C++, MATLAB, Shell Scripting Experience with parallel processing on HPC No publications (...yet. Working on one, but MY GOD this is tough) Only two research experiences: the second one is what I am pursuing my masters on right now; Current guide writes well and most probably gave me a solid reco, courtesy of good work (I hope) and 2+ years of familiarity with my work GRE: 324/340 (V:161; Q:163) TOEFL iBT: 115/120 (W:30; R:30: L:28; S:27)   (If you are working on this right now, watch a ton of Hollywood and BBC stuff. Work towards understanding everything without subtitles) Multiple extra curricular activities (this is important; otherwise work on showing a good personality during the interview; show what activities have contributed to building the personality). I have been coordinator for some or the other dept. for multiple events in college and otherwise.

Were the rejections mostly from reach schools/schools with less funding for international applicants? Do you have more matches/safeties that you haven't heard from? Some programs had late application deadlines, so it also makes sense for them to send interviews later than the others. If you really think it's not going to end up well this cycle, it might be worth looking into other options (biotech jobs, spring enrollment programs).
Not that I'm any more experienced with any of it, but if you want more detailed feedback on your app materials or have specific questions, feel free to DM me. And I hope you always remember that a rejection is not a rejection of your person; it's just the negation of a proposed match between what a program wants at a particular time and the words and numbers they choose to see you through.