In my freshmen's year , I was not able to attend one of the exams but forgot to get a medical certificate on time so I got an F. After taking the same course in second year I got an A+, however I guess this F will really look ugly on my transcript. My professor agreed to clarify it for me maybe in the recommendation letter(or should I also clarify the issue in CV or something?), but I'm still worrying about it. So will it be an impact for my application?