My daughter sent in 5 applications for PhD programs in Microbiology in January. She getting was very nervous, but has had 3 invitations to interview during the past week. One of those is from Baylor College of Medicine, Dept. of Molecular Virology and Microbiology. They are flying her to Houston on Thursday, Feb. 9th for a three day visit. She had a 3.26 GPA, but lots of research experience and great LORs. GRE was 159/161/4.5. I think that if you can write compelling essays, have good recommendations, and demonstrate that you have actually done valid research, you still have a chance, even late in the game. Good luck to all of you.