i'm from winston too! and no, i would not move back.
i would, however, move back to other parts of NC, and plan to do so in the future...
i think it really just depends on what you're looking for. north carolina is an incredibly beautiful state, with all the "good stuff"- beaches, mountains, lakes, etc. winston salem can be wonderful for raising a family, but it's also (still, though i know it's changed some) fairly conservative. however, that might be what you're looking for...
i went to undergrad in chapel hill, and the research triangle area is a totally different vibe. very liberal, very progressive, very fun.
then there's charlotte, which is somewhere in between.
can i ask what you're looking for and why you might be moving there? it would be easier to tell you what it's like and what kind of areas you might be interested in.