Just visited KU and their EEB program, and I thought Lawrence was pretty rad for its size. Keep in mind, I'm a Berkeley student and a SF native, so I can be quite critical about quality of life comparisons. Knowing that KU was smaller, I was still pleasantly surprised. Massachusetts street was awesome and there was decent food, book stores, music stores, and live music venue (live music, especially indie rock and folk seems like a big part of Lawrence, actually). I hear that w hen it's not freezing-ass cold outside, you get a lot of buskers (street musicians) outside. I absolutely *need* coffeeshops to be happy (I like to study in them), and there seemed to be plenty of non-starbucks coffeeshops. Even a nice, albeit not-so-great-for-studying, bar/coffee shop combo called the Bourgeois pig where they infused their own vodka and gin.
Having Kansas City nearby seems pretty rad. My PI, who had been to both Berkeley and New York City says she and her husband will often drive there for specific things they can't get in Lawrence, and it isn't all that far away.
I would say, yes, you do need a car. I'm going to be driving mine down from San Francisco. I'll also have a bike though, as I don't want to use my car unless weather is terrible or I'm getting groceries. Compared to Berkeley, KU seems to be a heaven for parking. There's no such thing as 2 hour residential parking, so you don't need a garage or a paid parking spot for your car. Be warned, if you have a fancy, expensive car, you'll probably want covered parking. Because of hale.
As for parking on campus, it seemed pretty possible to me. You'd probably have to be smart about it- I hear parking on west campus and taking the pretty frequent bus is the best option.
As for apartments, I absolutely detest modern apartment towers (both school owned and independent) in a small city like Lawrence, which has beautiful grand houses where they rent by the room or have subdivided them into studios. I'm looking at renting a room in a house or getting a one bedroom. Beware of land lords that have basically thrown up more walls and crammed their now-ruined houses with students. Look around for something nice. If your stipend is decent/you have some outside money/you're staying for at least 5 years, you should consider buying a house, putting down the ten percent, and paying the morgage and renting the spare room (s) to other students. It might make more sense.
I want non-bio friends! New KU grads should get together