Sure, they were very relevant to the topic of my publications. This research involved characterization of enzyme activity by phylogenetic and bioinformatic means, but also involved lab work. We determined active site residues and mutated those residues to change substrate specificity in the enzyme. PI asked how we determined the active site residues, how we mutated the residues, and what the new substrate specificity was (I didn't know the answer to this question, and said so. This work was done a couple years ago, and I wasn't involved in that portion). They also asked about my current organic synthesis project, how many steps, complexity, the applications to my overall greater project (synthesizing an unnatural amino acid for use in nucleic acid binding peptides).
So technical - not too much. Specific and relevant to my research, yes. Presumably, most of us here will know what our own research was about.