Wife Hates Physics

PLAN. No seriously, plan it out. Price things out, read reviews on companies, look at the areas surrounding prospective schools for housing costs, etc. My wife and I have made a cross-country move before on a very tight budget. Information is your key, and being upfront about the requirements with your partner. I'm in the current grad application cycle. My wife and I have discussed each possible school in detail, located the areas we can afford to move to, checked out the quality of the schools (for our two young ones), and she's evaluated the job market in each area for her profession. We are as prepared as possible for whichever school gives me a thumbs-up. There isn't really any other magic bullet. Know what you're getting into, make sure your partner is on the same page, and price everything out.