Thanks pterosaur and ChrisTOEFert for your thoughts. I do ultimately want to try for a professorship, but heck, we all know what a crapshoot that is. So I want to be relatively flexible with my PhD outcome - I am fully aware that a post-doc (if not 2) will be needed, regardless of where I pursue my PhD. It seems like both of you are saying that the institution where I pursue my PhD will somewhat over-ride the fact that it's a UK PhD when I'm applying for jobs. Makes sense, although I heard that it's more about the publications you have under your belt. E.g., Cambridge PhD won't help much if you don't have a single publication in a high impact journal. Thoughts?