Reviewer 1: "The technical approach is systematic, well-resourced, and likely to succeed in [its objectives]. Letters are strong, citing independence, initiative, and consistent engagement in scientific discussion during lab meeting. The transcripts are puzzling, with several low grades in relevant coursework. Many brilliant scientists do not achieve high marks in traditional coursework, but the application should provide some contextual information [for these low grades]."
Reviewer 2: "Though, low GPA during undergrad is a concern, the applicant provides a highly original self-developed research proposal. The proposed studies are highly challenging but have a great potential in [advancing knowledge of the field]. Previous research experiences of the applicant in both wet lab settings and bioinformatics perfectly suit the applicant's current proposal. The applicant also is well supported by strong supporting letters... Overall the applicant demonstrated outstanding research performance and provides a high quality research proposal."
Rejected. Not even an honorable mention.
Glad to know that academia cares more about grades than the proposal, whilst simultaneously and explicitly acknowledging that grades are not reliable indicators of research ability or potential. And with that, I am officially giving up on neuroscience and the PhD pursuit. Academia wouldn't even give me one single interview in my third cycle applying, yet somehow I'm good enough to bag a $85K/yr entry-level job in industry working with Feng Zhang. Re-read that last sentence and think about how messed up the academic processes must be for that to occur.
(For the context of those outside of biology, though Jennifer Doudna won the Nobel Prize in 2020 for the discovery of the gene-editing molecule CRISPR Cas9 [recall headlines about designer babies], Feng Zhang was independently working on it at the same time and was the first to engineer and prove its efficacy in mammalian cells. Many believe that he should have shared the Nobel Prize. That's who I'll be working with.)
TLDR: I'm done waiting for academia to recognize me. I'm moving on.
Best of luck to everyone else in your ongoing PhD pursuits! Keep your head up, take care of your mental health, and don't forget that there's always great opportunities out there - even if you can't immediately see them.