Go with your strongest “hands-on research” recommenders first: your current biotech boss (PhD) and the postdoc you worked with for 2 years, especially since you have a paper in review with her.
For the third, pick whoever can give the most specific, detailed support (either the professor who knows you academically or the lab professor if she can clearly describe your skills).
I’d avoid any weak or forced letters, and definitely skip a PI who doesn’t support you.