I agree about the loss of variety. I guess it doesn't matter with toothpaste, but it might matter more with food. I do get a good deal on my CSA (community supported agriculture) box that changes each week, so that provides us with some variety.
I don't enjoy going to the store that much, so the delivery aspect appeals to me. I think I might just stick with it for staples like rice, pasta, beans, etc. I really like not having to think about what I need to buy, making a list, and then having to go to the store. My experience has been mostly positive for my other subscribe and save items except when it's raining!