Hey, this thread is for me! I have a rather unusual academic history. I've been to four undergraduate institutions of varying sizes and reputations, and I have transferred back and forth between them several times, and changed my majors more times than I dare mention (hint: the number can't be counted on both hands put together). At the school I am graduating from, my GPA is pretty good (right now, I'm at a 3.52), my GPA in my major in awesome (3.8).
I have had a great 2 and a half years as a biology major, but prior to that, I was all over the place (both physically and academically). There were semesters that I had a 4.0, and there were semesters that I completely crashed and burned. I computed my overall GPA across all schools when filling out my apps, and came up with a 2.65. The reason for all this nonsense is that I had a lot of personal issues and anxiety problems, and rather than try to solve the problems and get on with life, I just kind of floundered and changed majors whenever I really screwed up.
The good news is that I was never a science major during all of this, so all of my poor grades are in completely unrelated courses. I think that I have certainly proven that I can handle the rigors of scientific study during the past 2.5 years, and my professors have told me that graduate schools will put a lot more weight on my great science grades than on my mediocre IT and Literature grades. I hope they're right. I would feel better about my apps if I did stellar on my GRE, but my quantitative score was a little low (64th percentile), which is weird because I really am quite good at math. However, I do feel good about the rest of my application - the SOP and LOR, plus my CV/resume show some research experience, along with some field work.
I figure that if I can't get into any PhD programs, I have a good shot at getting into a Biology M.S. program close to home at a state school, which I am still debating on applying to. The deadline isn't until April or May, and I was thinking why waste money on the application fees and sending GRE scores if I'm accepted to a PhD program, but I've been getting really nervous about my chances of getting in!