I've run through 2 rounds of rejections, then took a break from academia (to work a 9 to 5 [actually a 4 to Midnight]), just to see what kind of option that would be for me. Best advice I have is to have a couple back-up plans. After you finish applications start asking around and see if there are any Research Assistant jobs that will keep you doing what you are going to be doing. Keep in mind that often it is hard to get a paid RA job unless you've spent some time interacting with them. Think what options you have that will still move you toward your goal. For me, the hardest part of dealing with the rejections is more of the "now what" situation. The "I've spent all this time and energy on this thing and I didn't get in, I'm screwed." situation. So, having back up plans that will keep me working for what I want make everything a lot easier to handle. It still sucks hard to be rejected, but knowing that this rejection won't be the end of this journey keeps that from becoming a crushing loss. My backup plans stand as: Try to get full time work at my current Per Diem RA positionTeach Statistics (any level)Do research consulting or be a statistical adviser on researchContinue working on my 4 current projects until they are publishedWork as an educational advocate for students with disabilitiesIf I don't get in this year, I'm only going to get better with time. It is frustrating, because I can feel my time slipping away (I don't want to be gunning for tenure at 50), but I also know that I'll get there eventually. People already mistake me for faculty or ask me about their dissertations etc. I figure if I'm in it long enough everyone will just forget that I don't actually have a degree yet ;-)